Garstang - Inflammation and bone health - The Essentials

Garstang Support Group 

Guest speaker Dr. Ben Mulhearn PhD MRCP Consultant Rheumatologist Morecambe Bay NHS Trust will be giving a presentation on the topic of "Inflammation and bone health: The Essentials"

The talk aims to cover the following:
• How osteoporosis (OP) is a result of a complex interplay of factors, including cellular senescence, oxidative stress, inflammation, and hormonal imbalances.
• Overview of inflammation and what causes it.
• Explanation of the different types of inflammation in the body
• Overview regarding the similar signalling pathways in the different conditions and how associated cellular and molecular mechanisms may be associated with osteoporosis
• Overview regarding disruption of these pathways, combined with oxidative stress and chronic inflammation and resulting bone loss.
• Effect of Oestrogen and other sex hormones deficiency; increase of pro-inflammatory cytokine production; increase osteoclast differentiation leading to accelerated bone resorption
• How cellular senescence and oxidative stress contribute to reduced osteoblast function
• How chronic inflammation and oxidative stress further exacerbates the imbalance in bone remodelling
• Relationship between OP; osteoarthritis and reduced BMD and how impaired trabecular mineralization can alter cartilage and subchondral bone structure
• Mitochondrial dysfunction in bone cells as a potential driver of skeletal aging and OP.

Following the presentation attendees should benefit by:
• Understanding the effect of inflammation on the body
• Knowing how certain inflammatory conditions can increase the risk of having OP
• Knowing what steps to take to reduce inflammation

The event has already proven to be popular and there is now a waiting list in operation for this talk. We aim to repeat the talk on-line in the future for those that live further afield and for those that we couldn’t accommodate on the day.

Contact: Dawn Oliver garstangvolunteers@theros.org.uk to book a free place at our Garstang Osteoporosis Support Group events.